This study developed and evaluated silver sulfadiazine (SSD)-loaded hydrogel films based on sodium alginate (SA) and basil seed mucilage (BSM) for controlled topical delivery. Films were formulated by varying SA (800–1000 mg) and BSM (50–200 mg) with calcium chloride (CaCl2) (5–15%) as the crosslinker and propylene glycol (15% w/w) as a plasticizer. The optimized film (900 mg SA, 100 mg BSM, 10% CaCl2, 30 min) was selected for its superior integrity and swelling. Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy (ATR–FTIR), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), and X-ray Diffraction (XRD) confirmed SSD compatibility and uniform polymer dispersion. The optimized film exhibited high swelling (~38 g/g), moderate thickness (~609 μm), excellent flexibility (~252 folds), optimum tensile strength (0.454 kg/cm2) and good surface wettability (~48° contact angle), reflecting balanced hydrophilicity and mechanical strength. In vitro release followed Fickian diffusion (Korsmeyer–Peppas n 0.45), while additional evaluations confirmed appropriate water vapor transmission, microbial barrier properties, and hemocompatibility ( 5% hemolysis), supporting its biocompatibility. Overall, SA–BSM hydrogel films show strong potential as wound dressings, offering a stable, biocompatible matrix for sustained SSD delivery. However, as the study was limited to in vitro evaluations, further in vivo, stability, wound healing, and mechanical studies are warranted.
Mali et al. (Mon,) studied this question.