What question did this study set out to answer?

This review aims to explore the complex interactions between stress granules and tau pathology in Alzheimer’s Disease (AD).

June 3, 2026Open Access

Stress Granules and Tau Pathology in Alzheimer’s Disease: A Scoping Review of Bidirectional Interactions, Liquid-Liquid Phase Separation, and Proteostatic Consequences

Key Points

This review aims to explore the complex interactions between stress granules and tau pathology in Alzheimer’s Disease (AD).
Conducted a scoping review of literature on stress granules and tau pathology in AD.
Analyzed bidirectional interactions, liquid-liquid phase separation, and proteostatic consequences.
Evaluated potential therapeutic strategies involving SG modulation and autophagy enhancers.
Stress granules are linked to tau pathology and RNA dysregulation in AD.
Modulating stress granules may present a novel treatment approach for AD.
Autophagy enhancers, such as mTOR inhibitors and myricetin, show potential in diminishing tau pathology.

Abstract

• SGs are associated with AD through bidirectional interactions with tau pathology, RNA dysregulation, and proteostatic collapse. • SG modulation is a potential therapeutic strategy for AD. • Autophagy enhancers (mTOR inhibitors, myricetin), show promise in reducing tau pathology.

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Cite This Study

Kashtiban et al. (Mon,) studied this question.

synapsesocial.com/papers/6a1fc4bbdee9eb8c0dce64bc https://doi.org/https://doi.org/10.1016/j.brainresbull.2026.111974

Discussion

Journals

Brain Research Bulletin

Institutions

Shahid Beheshti University of Medical Sciences

Tabriz University of Medical Sciences

Islamic Azad University of Ahar

References and Citations

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