ABSTRACT Triboelectric nanogenerators (TENGs) have emerged as a promising approach for generating mechanical energy and facilitating sustainable biomedical technologies. However, conventional TENG materials usually rely on synthetic polymers that raise environmental and cytocompatibility concerns, highlighting the need for biomaterial and clinically translational alternatives. Natural polysaccharides offer extraordinary advantages, including biodegradability, bioactivity, tunable surface chemistry, and mechanical flexibility, making them suitable materials for next‐generation triboelectric biomedical applications. This review discussed the fundamental principles of triboelectric polysaccharides, their chemical structures, dielectric modulation, and surface engineering to improve electrical output performance. Recent advanced fabrication strategies, such as chemical functionalization, formulation, micro‐ and nanosurface texturing, 3D‐printed architectures, and nanocomposites, are critically discussed to highlight the development of high‐efficiency polysaccharide‐based TENGs (P‐TENGs). Special emphasis is placed on biomedical applications, particularly tissue regeneration, where triboelectric charges regulate cell migration, proliferation, angiogenesis, tissue remodeling, and antibacterial effects. Emerging applications favor bone, cardiac rhythm regulation, and neural repair. Polysaccharide‐based TENGs represent a sustainable and transformative platform for regenerative medicine and eco‐friendly bioelectronics.
Sivaraj Mehnath (Sun,) studied this question.