The magnitude of blood pressure dipping was strongly negatively correlated with frailty phenotype (B=-2.6; p=0.01) and vascular ageing (B=-0.7; p=0.05) in older adults.
Cross-Sectional (n=92)
Is the magnitude of blood pressure dipping associated with frailty and vascular ageing in community-dwelling older adults?
In community-dwelling older adults, a reduced magnitude of nighttime blood pressure dipping is associated with increased frailty and vascular ageing.
Effect estimate: B=-2.6 for FP
p-value: p=0.01
Objective: Ageing (chronological and vascular) and blood pressure changes are established risk factors for cardiovascular events. Dipping describes the natural drop in blood pressure during sleep (nighttime), with non-dipper status associated with increased cardiovascular risk. However, not much is known about dipping and its association with frailty. In this study the relationship between the magnitude of dipping, frailty, and vascular ageing was explored. Design and method: Cross-sectional analysis was performed on 92 community-dwelling adults who had 24-hour ambulatory blood pressure monitoring (ABPM) as part of the cardiovascular Frailty (c-FRAIL) study. Fried's Frailty Phenotype (FP) and the Clinical Frailty Score (CFS) were used to assess frailty. Dipping was derived from the DIASYS-3 PLUS (Novacor®) device used for ABPM, and vascular ageing determined with carotid-femoral pulse wave velocity (cf-PWV) using COMPLIOR®. Results: The mean age 75 ± 7, 50% male. Mean CFS was 3.5 ± SD 0.98 and mean FP 2.0 ± SD 1. Average day and night blood pressure readings were 120/70mmHg, and 110/87mmHg respectively. Among the participants, 36 (39.1%) were non-dippers, 30 (32.6%) dippers, 10 (10.9%) extreme dippers and 16 (17.4%) reverse dippers. The magnitude of dipping negatively correlated with frailty, FP (r=-0.3; p=0.002), CFS (r=-0.3; p=0.02), and vascular ageing cf-PWV (r=-0.3; p=0.01). In a regression analysis adjusting for age, gender, and mean 24hr SBP, there was a strong negative correlation with FP (B=-2.6; p=0.01) and cf-PWV (B=-0.7; p=0.05). Conclusions: The magnitude of dipping is associated with both frailty and vascular ageing, suggestive of the close link between aortic stiffness and frailty parameters
Mensah et al. (Fri,) conducted a cross-sectional in Frailty and vascular ageing in older adults (n=92). Magnitude of blood pressure dipping was evaluated on Frailty Phenotype (FP) and vascular ageing (cf-PWV) (B=-2.6 for FP, p=0.01). The magnitude of blood pressure dipping was strongly negatively correlated with frailty phenotype (B=-2.6; p=0.01) and vascular ageing (B=-0.7; p=0.05) in older adults.