Progress in research on TCM for treating gouty arthritis via relevant signaling pathways

Key Points

• This research reviews the relationship between key signaling pathways and gouty arthritis, highlighting Traditional Chinese Medicine (TCM) interventions.
• Review of signaling pathways including NF-κB, NLRP3, Nrf2, PI3K/Akt related to gouty arthritis.
• Analysis of TCM herbal monomers and compound efficacy on inflammatory response and oxidative stress.
• Discussion on the need for further experimental studies and clinical trials to clarify pathway interactions.
• TCM interventions were found to suppress inflammation and alleviate oxidative stress in gouty arthritis.
• Interventions improved joint function through modulation of autophagy and apoptosis.
• Future exploration of the 'state-target theory' is suggested to better identify TCM targets for precise treatment.