Hypertension was associated with significantly higher TgG index, TG BMI, and TG/HDL ratio compared with normotension (p<0.001), suggesting their potential utility in risk reclassification.
Cross-Sectional (n=1,866)
Yes
Do novel cardiovascular risk biomarkers (TgG index, TG BMI, Tg/HDL ratio) differ between normotensive and hypertensive individuals?
Novel cardiovascular risk biomarkers such as TgG index, TG BMI, and Tg/HDL ratio are significantly higher in hypertensive patients compared to normotensive individuals, suggesting potential utility in risk reclassification and treatment assessment.
p-value: p=<0.001
Objective: This study compared novel cardiovascular risk biomarkers—triglyceride glucose index (TgG), Tg BMI (TG BMI), and Tg/HDL cholesterol ratio—between normotensive and hypertensive individuals to inform future prevention and treatment strategies.Design and method: This cross-sectional analysis was conducted within the nationwide EH-UH 2 project and included a representative random sample of non-institutionalized adults.. We analysed 550 subjects with controlled hypertension (mean age 54, 21,5% men), 255 subjects uncontrolled hypertension (mean age 54, 15,2% men), 386 subjects with untreated hypertension (mean age 62, 23% men), and 675 normotensive subjects (mean age 53, 40,3% men). Using routine laboratory methods we determined lipids and new CV risk biomarkers: total cholesterol (T-Ch), HDL-ch, LDL-Ch, triglycerides (Tg), fasting blood glucose (G), and calculated TgG index, Tg/HDL and TG BMI. The definition and classification of hypertension followed the ESH guidelines. Results: Normotensive patients showed more favourable values of novel biomarkers compared with hypertensive subgroups. They had significantly lower TgG index, TG BMI, and TG/HDL ratio compared with all hypertensive subgroups (p<0.001). Additionally, the highest TG BMI values were observed in untreated and uncontrolled hypertension (p<0.001), whereas controlled hypertension had significantly lower TgG index values compared with untreated hypertension (p<0.001) and uncontrolled hypertension (p=0.003). Tg/HDL ratio was significantly lower in normotensive individuals than in untreated and uncontrolled hypertension (p<0.001) but did not differ significantly compared with the controlled hypertensive subgroup (p=0.105). Conclusions: All three analysed CV risk biomarkers are higher in hypertensive than in normotensive subjects indicating that they might be useful in risk reclassification. TgG and TG BMI were significantly lower in controlled than in uncontrolled hypertensive subjects pointing that these biomarkers could be additional tool for better assessment of global treatment success. These cheap and available biomarkers seem to be promising, however longitudinal studies with more patients are need for determination of their potential role in prevention and management of hypertension.
Štimac et al. (Fri,) conducted a cross-sectional in Hypertension (n=1,866). Hypertension vs. Normotension was evaluated on Novel cardiovascular risk biomarkers (TgG index, TG BMI, and Tg/HDL ratio) (p=<0.001). Hypertension was associated with significantly higher TgG index, TG BMI, and TG/HDL ratio compared with normotension (p<0.001), suggesting their potential utility in risk reclassification.