Preparation of a platycodin D microsphere gel and evaluation of its therapeutic effects on osteoarthritis in rats

Key Points

• This research aims to investigate the therapeutic effects of a Platycodin D microsphere gel on osteoarthritis in a rat model.
• Developed a thermosensitive Platycodin D microsphere gel for intra-articular delivery.
• Conducted evaluation of its effects on cartilage protection in rats with osteoarthritis.
• Demonstrated significant cartilage protection in rats treated with Platycodin D microsphere gel compared to control.
• Sustained therapeutic effect noted over the intervention period.