Selective 1,2-addition of acetonitrile/acetone to α,β-unsaturated aldehydes at room temperature: access to cinnamyl alcohol derivatives with potential protective effects against exercise-induced skeletal muscle injury | Synapse
June 3, 2026RSC Advances0 citationsOpen Access
Selective 1,2-addition of acetonitrile/acetone to α,β-unsaturated aldehydes at room temperature: access to cinnamyl alcohol derivatives with potential protective effects against exercise-induced skeletal muscle injury
The aim is to explore a selective method for synthesizing cinnamyl alcohol derivatives with potential benefits for muscle injury recovery.
Developed an electrocatalytic 1,2-addition process at room temperature.
Synthesized 38 cinnamyl alcohol derivatives in mild reaction conditions.
Successful production of 38 different cinnamyl alcohol derivatives.
Demonstrated potential protective effects against exercise-induced skeletal muscle injury.
Abstract
An electrocatalytic selective 1,2-addition of acetonitrile/acetone to α,β-unsaturated aldehydes at room temperature was developed, providing 38 cinnamyl alcohol derivatives in mild reaction conditions.