Objective: To investigate the relationship between body fat mass (BFM) and hyperuricemia (HUA) in adolescents, and to analyze the mediating role of inflammatory factors between BFM and serum uric acid (SUA), so as to provide a scientific basis for the prevention and treatment of HUA in adolescents. Design and method: Using stratified cluster sampling, 1055 adolescents aged 12–18 years were selected from urban areas of Yinchuan City in 2020 and 2023. All participants completed questionnaires, physical examinations, and blood biochemical tests. Correlation analysis was used to assess the relationship between BFM and SUA; logistic regression models combined with restricted cubic splines were applied to analyze the association between BFM and HUA; and a mediation effect model was used to examine the mediating role of inflammatory factors in the relationship between BFM and SUA. Results: BFM was positively correlated with SUA (r = 0.23, P < 0.001). After adjusting for confounders, the highest quartile of BFM had a 9.02-fold increased risk of HUA compared with the lowest quartile (95% CI: 5.43–14.97). A nonlinear dose–response relationship was observed between BFM and HUA risk (P for trend < 0.001, P for nonlinearity < 0.05). The mediating effects of C-reactive protein and irisin in the relationship between BFM and SUA were 0.16 (95% CI: 0.04–0.31) and 0.19 (95% CI: 0.07–0.32), respectively, accounting for 5.9% and 7.6% of the total effect (both P < 0.05). Conclusions: Increased body fat mass is associated with a higher risk of hyperuricemia in adolescents, and inflammatory factors partially mediate this relationship. Prevention and management of hyperuricemia in adolescents should focus on individuals with high body fat mass and monitor levels of relevant inflammatory factors.
Wang et al. (Fri,) studied this question.