3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors

Key Points

• This study aims to explore the efficacy of 3-hydroxypyrimidine-2,4-dione derivatives as inhibitors of the monkeypox virus resolvase.
• Developed an in vitro assay to measure the activity of orthopoxvirus resolvases.
• Focused on the inhibition of monkeypox virus resolvase specifically.
• Conducted tests on various 3-hydroxypyrimidine-2,4-dione derivatives.
• Identified significant inhibition of monkeypox virus resolvase activity by specific derivatives.
• Noted a reduction in viral genome replication with lower concentrations of the inhibitors.
• Demonstrated potential for these compounds in developing antiviral therapies against monkeypox.