What does this research mean for the field?

Asymmetric deoxy-fluoroalkylation of amides can be achieved through transimination with Ellman's sulfinamide to form chiral sulfinimines, followed by diastereoselective fluoroalkylation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To explore the impact of transimination on the formation of chiral sulfinimines and its application in diastereoselective fluoroalkylation.

June 4, 2026Organic Letters0 citations

Asymmetric Deoxy-Fluoroalkylation of Amides Enabled by Transimination

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JWJason A. Wilt SMSamirah Muhammad RRR. Yasoda. H. Rajapaksha

Key Points

To explore the impact of transimination on the formation of chiral sulfinimines and its application in diastereoselective fluoroalkylation.
Utilized Ellman's sulfinamide for transimination
Formed chiral sulfinimines
Conducted diastereoselective fluoroalkylation
Successfully created chiral sulfinimines
Achieved diastereoselective outcomes clearly marked by success in fluoroalkylation

Abstract

transimination with Ellman's sulfinamide to form chiral sulfinimines, and diastereoselective fluoroalkylation.

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Asymmetric Deoxy-Fluoroalkylation of Amides Enabled by Transimination

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Abstract

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