Covalent grafting of hyaluronic acid on drug nanocrystals for mucosal delivery

Key Points

• This research aims to enhance drug delivery by modifying nanocrystals with hyaluronic acid for better mucosal penetration.
• Covalent grafting of hyaluronic acid onto curcumin nanocrystals
• Evaluation of mucosal penetration and drug deposition efficiency
• Surface-modified curcumin nanocrystals showed significantly improved mucosal penetration
• Increased drug deposition indicated a more effective targeted delivery platform