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Spaceflight imposes substantial physiological stress on reproductive systems, yet relevant transcriptomic data remain fragmented across repositories. To address this need, we developed ASTROREPOMICS, a web-based platform that integrates 17 rigorously normalized and batch-corrected transcriptomic datasets spanning multiple species and reproductive tissues. The platform supports reproducible cross-study and cross-species analyses through standardized metadata and an intuitive user interface. We highlight its utility through two example analyses: (1) irradiated mouse sperm exhibited suppression of RNA splicing and protein-processing pathways alongside activation of interferon- and GPCR-associated programs; and (2) a multi-species intersected-DEG assessment between irradiated rat mammary tissue and microgravity-exposed zebrafish embryos uncovered conserved signatures involving RNA metabolism, cytokine signaling, and angiogenesis. By consolidating dispersed datasets and offering tailored analytical capabilities, ASTROREPOMICS provides a centralized resource for hypothesis generation and strengthens the research infrastructure needed to advance reproductive health studies in space, supporting long-term efforts to safeguard fertility during deep-space exploration.
Lung et al. (Wed,) studied this question.