What does this research mean for the field?

IL-24 drives sepsis pathogenesis by promoting bacterial dissemination and inflammatory amplification, and inhibiting its expression significantly reduces sepsis-associated mortality. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to understand the role of IL-24 in sepsis and its potential as a therapeutic target.

June 5, 2026Virulence0 citationsOpen Access

The dual pathogenic role of IL-24 in sepsis: Coupling bacterial dissemination with inflammatory amplification as a therapeutic target

JLJinjin Lu YLYuan Liao ZLZhongshuang Liu

Key Points

This research aims to understand the role of IL-24 in sepsis and its potential as a therapeutic target.
Performed experiments using recombinant IL-24 protein to study its effects on bacterial accumulation and leukocyte movement.
Measured sepsis-associated mortality following inhibition of IL-24 expression.
Recombinant IL-24 protein enhanced bacterial accumulation and leukocyte chemotaxis.
Inhibition of IL-24 expression significantly reduced sepsis-associated mortality.

Abstract

experiments revealed that recombinant IL-24 protein enhances the bacterial accumulation and leukocyte chemotaxis. Finally, inhibition of IL-24 expression significantly reduced sepsis-associated mortality. These findings suggest that IL-24 contributes to sepsis pathogenesis by promoting bacterial dissemination and inflammatory amplification, and identify IL-24 as a potential therapeutic target for the precise treatment of sepsis.

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