Molecular Dynamics and Docking Reveal Enhanced Binding of HPV16 E6 Asian American Variants To non-phosphorylated DLG1

Key Points

• Binding affinity of HPV16 E6 variants to DLG1 was significantly improved, highlighting potential virulence factors.
• Key evidence shows a 20% increase in binding affinity towards non-phosphorylated DLG1 compared to standard variants.
• Molecular dynamics simulations and docking studies were used to assess the binding interactions of HPV16 E6 and DLG1 variants.
• The findings may indicate the need for further research into HPV's role in diverse populations and disease mechanisms.