March 3, 2026Open Access

Camptothecin-PHA nanoparticles attenuate drug-induced gut microbiome dysbiosis and metabolic toxicity

Key Points

Nanoparticles reduce metabolic toxicity in the gut microbiome, promoting microbial balance.
This treatment shows effective mitigation of negative effects on intestinal flora and serum metabolism.
Analysis of a novel nanomaterial demonstrated its potential in promoting metabolic safety during therapy.
Implications suggest that addressing microbial balance may enhance overall treatment safety.

Abstract

In conclusion, this novel type of nanomaterial not only possesses excellent performance but also can reduce the impact of CPT on tissues, intestinal flora and serum metabolism, providing a new strategy for anti-tumor treatment that takes into account both microbial homeostasis and metabolic safety.

Camptothecin-PHA nanoparticles attenuate drug-induced gut microbiome dysbiosis and metabolic toxicity

Key Points

Abstract

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