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March 3, 2026
The Methylcytosine Dioxygenase Tet2 Influences Outcomes of Graft-Versus-Host Disease through Regulation of Donor T-Cells
SS
Samara P. Singh
Johns Hopkins University
MD
Margarita Dionysiou
Johns Hopkins University
SW
Sarah Watt
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Key Points
Graft-versus-host disease outcomes are influenced by the regulation of donor T-cells through Tet2.
Findings indicate that altered function in Tet2 impacts disease severity and immune response metrics.
Analysis involved assessing methylcytosine levels and T-cell function in a controlled experimental setup.
Further studies are needed to explore Tet2's potential as a therapeutic target in clinical settings.
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The Methylcytosine Dioxygenase Tet2 Influences Outcomes of Graft-Versus-Host Disease through Regulation of Donor T-Cells | Synapse
Cite This Study
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Singh et al. (Sun,) studied this question.
synapsesocial.com/papers/69a760dfc6e9836116a2e079
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.324