Accelerated epigenetic aging as a modifier of homocysteine‐associated cognitive decline: Findings from NHANES

Key Points

• This research aims to explore how accelerated epigenetic aging impacts cognitive decline associated with homocysteine levels.
• Analyzed data from NHANES
• Assessed the relationship between homocysteine and cognitive function
• Investigated the role of epigenetic aging and neuroinflammation
• Higher homocysteine levels are linked to increased cognitive decline.
• Epigenetic aging exacerbates the cognitive effects of hyperhomocysteinemia.
• Folate shows protective effects by lowering homocysteine levels.

Abstract