What question did this study set out to answer?

The aim is to explore how CCN5 contributes to muscle homeostasis and prevents age-related muscle loss.

April 10, 2026Open Access

Dual Roles of CCN5/WISP2 in Cytosol and Secretome for Maintaining Muscle Homeostasis and Preventing Sarcopenia

Key Points

The aim is to explore how CCN5 contributes to muscle homeostasis and prevents age-related muscle loss.
Analyzed the effects of CCN5 on muscle cells
Assessed mitochondrial function and interactions
Investigated pathways related to myosteatosis
CCN5 effectively reduces myosteatosis
Promotes mitochondrial biogenesis
Enhances interactions between lipid droplets and mitochondria

Abstract

CCN5 mitigates myosteatosis and counteracts sarcopenia by promoting mitochondrial biogenesis and enhancing LD-Mt interactions through dual pathways, positioning it as a promising therapeutic target for muscle aging and sarcopenia.

Dual Roles of CCN5/WISP2 in Cytosol and Secretome for Maintaining Muscle Homeostasis and Preventing Sarcopenia

Key Points

Abstract

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