TNFRSF1A (−135 T>C, rs767455) Polymorphism as a Predictor of Radiation Induced Oral Mucositis and Treatment Response in Locally Advanced Head and Neck Cancer Patients

Key Points

• To explore the impact of the TNFRSF1A (-135 T>C) polymorphism on radiation-induced oral mucositis and treatment outcomes in head and neck cancer patients.
• Analyzed the TNFRSF1A (-135 T>C) polymorphism in patients with locally advanced head and neck cancer
• Assessed toxicity (oral mucositis) and treatment response in relation to genotypes
• Compared outcomes based on C allele versus TT genotype
• The C allele is associated with a higher risk of developing oral mucositis
• Patients with the TT genotype show more favorable treatment responses
• TNFRSF1A polymorphism may serve as a biomarker for personalized radiotherapy in head and neck cancer patients