What does this research mean for the field?

Significant eccentricity index elevation (EIs > 1.28) differentiates children with and without pulmonary arterial hypertension after complete atrioventricular septal defect repair. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association between eccentricity index (EI) and pulmonary arterial hypertension (PAH) in children who underwent repair of complete atrioventricular septal defects (AVSD).

April 10, 2026Open Access

Eccentricity Index Is Associated With Pulmonary Arterial Hypertension in Children After Repair of Complete Atrioventricular Septal Defects

Key Result

Significant eccentricity index elevation (EIs > 1.28) differentiates children with and without pulmonary arterial hypertension after AVSD repair.

Key Points

To evaluate the association between eccentricity index (EI) and pulmonary arterial hypertension (PAH) in children who underwent repair of complete atrioventricular septal defects (AVSD).
Measured eccentricity indices (EI) in children post AVSD repair
Compared EI values with those of healthy children
Identified cutoff values for differentiating PAH presence
Elevated EIs observed in children after AVSD repair compared to healthy peers
Significant elevation found with Eis > 1.28 to differentiate PAH
Borderline EIs (1.09-1.28) may require a multiparametric assessment

Structured PICO

Does the Eccentricity Index identify pulmonary arterial hypertension in children after repair of complete atrioventricular septal defects?

Population

Children after repair of complete atrioventricular septal defects (AVSD)

Intervention

Eccentricity Index (EI) measurement (EIs and EIm)

Comparator

Otherwise healthy children and children without pulmonary arterial hypertension (PAH)

Outcome

Identification of pulmonary arterial hypertension (PAH)surrogate

Eccentricity Index (specifically EIs > 1.28) can serve as a useful non-invasive screening tool to identify pulmonary arterial hypertension in children following AVSD repair.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

After AVSD repair, EIs and EIm are elevated compared to those of otherwise healthy children. However, significant elevation (Eis > 1.28) may still be useful to differentiate those with and without PAH. A multiparametric approach may be needed for borderline EIs (1.09-1.28). These findings support EI as a non-invasive screening tool to identify PAH in children after AVSD repair.