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The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types. It is well tolerated in monkeys, with tissue Trop-2 expression similar to humans, at clinically relevant doses, and warrants clinical investigation.
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Cardillo et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69de37b01c2d3320f8b0be9e — DOI: https://doi.org/10.1158/1078-0432.ccr-10-2939
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
Thomas M. Cardillo
Serengulam V. Govindan
Robert M. Sharkey
Clinical Cancer Research
Center for Molecular Medicine and Immunology
Immunomedics (United States)
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