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This research examines the effects of deep brain stimulation compared to best medical treatment on cognitive and motor functions in Parkinson's disease patients.

April 15, 2026

Deep brain stimulation or best medical treatment for Parkinson’s disease patients: 36-month longitudinal neuropsychological and motor assessment — a prospective case-control study

Key Points

This research examines the effects of deep brain stimulation compared to best medical treatment on cognitive and motor functions in Parkinson's disease patients.
Prospective case-control design
Longitudinal assessment over 36 months
Comparison of cognitive and motor outcomes between DBS STN and medical treatment groups
Use of UPDRS III to measure motor severity
DBS STN did not show significant improvements in cognitive performance compared to medical treatment
Active DBS STN improved motor symptoms but could not reduce worsening of OFF-motor severity
Motor symptom progression was similar between both treatment groups over the study period

Abstract

The study suggests that DBS STN does not have a significant additional impact on cognition performance in PD patients. Our results also suggest that while active DBS STN continues to improve motor symptoms, it did not prevent the longitudinal worsening of OFF-motor severity (UPDRS III OFF), which progressed similarly in both groups.

Deep brain stimulation or best medical treatment for Parkinson’s disease patients: 36-month longitudinal neuropsychological and motor assessment — a prospective case-control study

Key Points

Abstract

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