Azelaic acid-integrated therapeutic deep eutectic systems: overcoming solubility and permeability barriers for enhanced transdermal drug delivery | Synapse
April 15, 2026Open Access
Azelaic acid-integrated therapeutic deep eutectic systems: overcoming solubility and permeability barriers for enhanced transdermal drug delivery
Key Points
The research aims to enhance the transdermal delivery of azelaic acid by integrating it into therapeutic deep eutectic systems.
Developed therapeutic deep eutectic systems with azelaic acid
Analyzed the solubility and permeability of the formulations
Conducted comparative assessments of transdermal delivery efficacy
Significantly improved solubility of azelaic acid in the developed systems
Enhanced permeability barriers led to increased drug absorption
Demonstrated effective transdermal delivery for skin disorders
Abstract
Azelaic acid (AzA) is a saturated dicarboxylic acid used to treat skin disorders like acne, rosacea, and melasma.