Groove pancreatitis, diagnosis, and management strategies: a case series

Abstract Groove pancreatitis (GP) is identified as an inflammatory process that entails the anatomical part that lies between the C-loop of the duodenum and the head of the pancreas as well as common bile duct. Diagnosis is often challenging due to the extensive similarities with pancreatic adenocarcinoma; therefore, histological examination is needed for a proper differentiation. We report a case series of two male patients with a history of alcoholism who presented with upper abdominal pain, nausea, and vomiting. Computed tomography revealed inflammatory changes around the head of the pancreas and duodenum, indicating GP. Conservative management formed the mainstay of treatment, with surgical intervention reserved for intractable symptoms and complications. Both patients responded well and were referred to hepatobiliary surgeons for further management. Early recognition is crucial to avoid misdiagnosis and to prevent unnecessary major surgery, underscoring the need for a detailed history, careful imaging interpretation, and multidisciplinary evaluation.