What does this research mean for the field?

MMP-1, MMP-8, and MMP-13 gene polymorphisms serve as potential markers for predicting susceptibility to oral mucositis in oncopediatric patients undergoing methotrexate treatment. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to determine if certain gene polymorphisms are markers for oral mucositis in pediatric cancer patients.

April 15, 2026Open Access

Oral Mucositis in Oncopediatric Patients: MTX and MMP ‐1, MMP ‐8, MMP ‐13 Gene Polymorphisms

Key Points

This research aims to determine if certain gene polymorphisms are markers for oral mucositis in pediatric cancer patients.
Analysis of gene polymorphisms in MMP-1, MMP-8, and MMP-13.
Assessment of oral mucositis occurrence and severity in oncopediatric patients.
Correlation of genetic variations with mucositis susceptibility.
Identified specific polymorphisms associated with increased risk of oral mucositis.
Proposed that genotyping may assist in personalizing treatment plans.
Indicated potential for reduced mucositis severity through tailored interventions.

Abstract

The study highlights the importance of these MMPs polymorphisms as potential markers for predicting susceptibility to oral mucositis, suggesting that these data could help tailor treatments to minimise the occurrence and severity of mucositis.

Oral Mucositis in Oncopediatric Patients: MTX and MMP ‐1, MMP ‐8, MMP ‐13 Gene Polymorphisms

Key Points

Abstract

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