Unusual occurrence of temporo-spatial cluster of human prion disease in northern part of central Slovakia

Key Points

• To explore the unusual occurrence of prion diseases in a specific area of central Slovakia.
• Conducted a comprehensive investigation of prion diseases in a confined population.
• Utilized systematic neuropathological confirmation and molecular testing.
• Emphasized the need for regional surveillance in monitoring prion diseases.
• Identified a unique cluster of distinct prionopathies.
• No specific explanatory factor found for the occurrence.
• The cluster appears to be a chance occurrence of epidemiological interest.