What question did this study set out to answer?

This research aims to investigate how a 24-week resistance exercise program affects brain signatures related to Alzheimer's disease in cognitively unimpaired older adults.

April 15, 2026Open Access

Effects of a 24-week resistance exercise program on Alzheimer’s disease brain signatures in cognitively unimpaired older adults: a secondary analysis of the AGUEDA randomized controlled trial

Key Points

This research aims to investigate how a 24-week resistance exercise program affects brain signatures related to Alzheimer's disease in cognitively unimpaired older adults.
Conducted a secondary analysis of the AGUEDA randomized controlled trial.
Participants engaged in a 24-week resistance exercise program.
Brain signatures were assessed pre- and post-intervention.
The resistance exercise program improved cognitive function indicators in participants.
Significant changes in brain signatures associated with Alzheimer's disease were noted after 24 weeks.

Abstract

Registered on Clinicaltrials.gov (Identifier: NCT05186090).

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Discussion

Journals

Age and Ageing

Institutions

University of Pittsburgh

Universidad de Granada

Instituto de Salud Carlos III

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