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Research Paper | Synapse

April 15, 2026Open Access

Premalignant Pathomorphology of the Liver in Chronic Hepatitis C: Clinicopathological and Immunohistochemical Correlations

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Key Points

The central aim is to investigate the premalignant changes in liver pathology due to chronic hepatitis C.
Analyzed liver tissue from patients with chronic hepatitis C
Evaluated morphological changes microscopically
Investigated immune-cell activity and fibrosis levels
Findings show significant morphological alterations in liver tissue due to chronic hepatitis C
Identified strong correlation between immune-cell activity and degree of liver fibrosis
Detected increased activation of Kupffer and hepatic stellate cells in fibrotic livers

Abstract

Background: Chronic hepatitis C (CHC) remains an important etiological factor for liver cirrhosis and hepatocellular carcinoma (HCC). Premalignant morphological changes in the liver are mediated by progressive fibrosis, necroinflammatory activity, immune-cell infiltration, and activation of Kupffer cells and hepatic stellate cells 1–4.

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Authors

U

Uktamboy Abdullayev

Tashkent Medical Academy

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Tashkent Medical Academy

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Cite this study

Uktamboy Abdullayev (Mon,) studied this question.

synapsesocial.com/papers/69df2c2fe4eeef8a2a6b13f8 — DOI: https://doi.org/10.5281/zenodo.19560186