Biofluid‐specific variations in circulating 5′ transfer RNA fragments during ictal and interictal states in experimental temporal lobe epilepsy

Key Points

• The research investigates the presence of 5'tRNA fragments in brain and plasma during different states of epilepsy.
• Analyzed biofluid samples from individuals with temporal lobe epilepsy during ictal and interictal states.
• Measured levels of 5'tRNA fragments in both brain and plasma.
• Conducted comparative analysis to assess differences in fragment accumulation.
• 5'tRNA fragments accumulate in the brain during interictal spike activity.
• 5'tRNA fragments are found at higher levels in the plasma of individuals with epilepsy.
• The findings support the potential of 5'tRFs as diagnostic biomarkers for epilepsy.