Resposta de Szczeklik et al à Carta Sobre o Artigo, “Ivabradina em Pacientes Submetidos a Cirurgia Não Cardíaca: Um Ensaio Controlado Randomizado”

“Ivabradine did not reduce the risk of MINS in patients undergoing noncardiac surgery. Heart-rate lowering was modest and the possible higher MINS incidence in patients with known coronary artery disease is contrary to our original hypothesis. Further research is needed to establish a method to safely control the heart's stress associated with noncardiac surgery.”