Supplementary Figure 19 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• SPP1 blockade notably alters CD8+ T-cell function, potentially reversing immunotherapy resistance.
• Key changes in CD8+ T cells were observed following SPP1 blockade, indicating its role in therapeutic responses.
• The approach involved assessing T-cell dynamics in clear-cell renal cell carcinoma after specific macrophage targeting.
• These findings highlight the important link between tumor-associated macrophages and T-cell dysfunction in cancer therapy.

Abstract