Dual metabolic restructuring against tumor acidosis and adenosine potentiates radioimmunotherapy via reinvigoration of CD8+ T lymphocytes

Key Points

• Radioimmunotherapy enhances T cell responses through targeting tumor acidosis and adenosine.
• The study indicates a potential increase in CD8+ T lymphocyte activity after treatment alteration.
• Assessment using innovative metabolic restructuring approaches suggests improved tumor response.
• These findings highlight the need for further exploration of metabolic strategies in cancer therapy.