Targeting lipophagy and nuclear receptors in metabolic-associated fatty liver disease: insights from traditional Chinese medicine

Key Points

• Therapeutic effects on metabolic-associated fatty liver disease are significantly linked to lipophagy induction and nuclear receptor activation.
• Active compounds from Traditional Chinese Medicine notably reduce side effects while enhancing efficacy in treating metabolic-associated fatty liver disease.
• Analysis of pharmacological mechanisms shows a variety of NR-associated signaling pathways involved in the treatment processes.
• Potential implications for drug development arise from these findings, highlighting the need for continued basic research in this area.