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TROP-2是一种糖蛋白,最初被描述为滋养层细胞的表面标志物,随后发现其在许多实体癌症中表达升高,而在某些正常组织中的表达较低。它通过多条信号通路调节癌症的生长、侵袭和扩散,并在干细胞生物学及其他疾病中发挥作用。本文综述了TROP-2的特性,特别是在癌症中的作用,尤其作为抗体药物偶联物(ADC)或免疫疗法的靶点。当伊立替康代谢物SN-38与人源化抗TROP-2抗体(sacituzumab govitecan)偶联时,在人类癌症异种移植模型及晚期三阴性乳腺癌、非小细胞肺癌、小细胞肺癌及尿路上皮癌患者中显示出强大的广谱抗癌活性。
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David M. Goldenberg
Rhona Stein
Robert M. Sharkey
Oncotarget
Center for Molecular Medicine and Immunology
Immunomedics (United States)
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Goldenberg等人(周五)研究了这个问题。
www.synapsesocial.com/papers/69cac1a5c138251ffc5f8151 — DOI: https://doi.org/10.18632/oncotarget.25615
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