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报道了一种利用可见光激活的2+2光环加成实现苯并呋喃及一例苯并噻吩的催化不对称脱芳构化的新方法,从而提供了具有多达四个立体中心(包括季碳立体中心)的手性三环结构。苯并呋喃和苯并噻吩在2位位点官能化有一个螯合的N-酰基吡唑基团,该基团可协调可被可见光激活的具有手性铑路易斯酸催化剂。计算分子建模揭示了异常区域选择性的起因,并确认杂环中的杂原子是调控区域选择性的关键因素。
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Naifu Hu
Hoimin Jung
Yu Zheng
Angewandte Chemie International Edition
Korea Advanced Institute of Science and Technology
Philipps University of Marburg
Institute for Basic Science
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Hu等人(星期五)研究了该问题。
www.synapsesocial.com/papers/69d78ff35f9a1dad5349088e — DOI: https://doi.org/10.1002/anie.201802891
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