June 1, 1988

日光反应性皮肤类型I至VI的有效性和实用性

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Abstract

1975年，日光反应性“皮肤类型”这一概念被创造出来，目的明确：对白种人进行分类，以便选择正确的紫外线A（UVA）初始剂量（单位为焦耳/立方厘米），用于当时新开发的治疗银屑病技术——口服甲氧沙林光化学疗法（PUVA）。需求来源于对若干患者的观察，这些患者为“暗”型表型（棕色甚至黑色头发，有些还带棕色眼睛），但出人意料的是，他们在口服0.6 mg/kg甲氧沙林两小时后，暴露于4至6 J/cm2的紫外线下，出现了严重的光毒性反应。显然这些初始剂量过高，这时人们认识到对白种人耐受口服PUVA的估计不能单纯基于表型（头发和眼睛颜色）。

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Thomas B. Fitzpatrick

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Archives of Dermatology

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Harvard University

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Thomas B. Fitzpatrick（Wed，）研究了这个问题。

www.synapsesocial.com/papers/69d805ad61e2ce1627d188e9 — DOI: https://doi.org/10.1001/archderm.124.6.869

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日光反应性皮肤类型I至VI的有效性和实用性

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