What question did this study set out to answer?

This research examines how changes in oral anticoagulant usage influence the incidence of intracerebral hemorrhage.

April 10, 2026Open Access

Changes in the use of vitamin K antagonists and direct oral anticoagulants and impact on the incidence of oral anticoagulation-related intracerebral hemorrhage: population-wide prescription patterns in two 5-year cohorts

Key Result

Direct oral anticoagulants had lower intracerebral hemorrhage rates than vitamin K antagonists, maintaining stable overall incidence despite near-doubled oral anticoagulant use.

Key Points

This research examines how changes in oral anticoagulant usage influence the incidence of intracerebral hemorrhage.
Analyzed population-wide prescription patterns
Compared two 5-year cohorts
Assessed incidence rates of intracerebral hemorrhage
Incidence of intracerebral hemorrhage remained stable despite increased use of oral anticoagulants
Direct oral anticoagulants showed lower intracerebral hemorrhage rates compared to vitamin K antagonists
Safety advantage of direct oral anticoagulants is supported by findings

Structured PICO

Do direct oral anticoagulants reduce the incidence of oral anticoagulation-related intracerebral hemorrhage compared to vitamin K antagonists?

Population

Population-wide cohorts of patients receiving oral anticoagulants over two 5-year periods

Intervention

Direct oral anticoagulants (DOACs)

Comparator

Vitamin K antagonists (VKAs)

Outcome

Incidence of oral anticoagulation-related intracerebral hemorrhage (ICH)safety

Population-wide data demonstrates that despite a near-doubling of oral anticoagulant use, intracerebral hemorrhage incidence remained stable, driven by the safety advantage of DOACs over VKAs.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

ICH incidence remained stable despite near-doubled OAC use. The lower ICH rates with DOACs compared to VKAs support their safety advantage.

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