What question did this study set out to answer?

The research aims to understand how long non-coding RNAs (lncRNAs) influence the pharmacokinetics and pharmacodynamics of methotrexate (MTX).

April 10, 2026Open Access

Regulatory Roles of Long Non-Coding RNAs in Methotrexate Pharmacology: Mechanistic and Translational Insights

Key Points

The research aims to understand how long non-coding RNAs (lncRNAs) influence the pharmacokinetics and pharmacodynamics of methotrexate (MTX).
Review current evidence on lncRNA functions in MTX pharmacology
Discuss the integration of functional genomics with pharmacokinetic measurements
Highlight the need for prospective clinical validation
lncRNAs act as context-dependent modulators rather than direct drug targets
Current evidence regarding lncRNAs in MTX regulation is inconsistent
Future studies are necessary to explore lncRNAs as biomarkers or therapeutic targets

Abstract

lncRNAs function as context-dependent modulators of MTX PK/PD processes rather than primary drug targets. Current evidence is heterogeneous, future studies integrating functional genomics, PK measurements, and prospective clinical validation are required to establish lncRNAs as predictive biomarkers or therapeutic targets in MTX precision pharmacology.

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Discussion

Journals

Pharmaceutical Research

Institutions

Instituto Politécnico Nacional

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Universidad Autónoma Metropolitana

References and Citations

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