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氨基糖苷类药物是治疗革兰氏阴性菌败血症患者的救命抗生素。约10%的氨基糖苷临床用药过程中会出现肾功能障碍。由于其药代动力学和毒理学的高度相似性,大鼠是比较这些抗生素肾毒性潜力的极佳人类模型。与临床比较相比,大鼠模型更为灵敏,因为临床肾功能测试缺乏敏感性,严重病患体内存在干扰因素,且临床上无法进行形态学比较。尽管全球范围内已广泛研究,氨基糖苷肾毒性的发病机制尚在不断深入探讨中。然而,这些研究推动了多种氨基糖苷肾毒性抑制剂的鉴定。这些抑制剂的临床应用价值仍需进一步确认。
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G. H. Hottendorf
Patricia D. Williams
Toxicologic Pathology
Bristol-Myers Squibb (United States)
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Hottendorf 等人(星期三)研究了这一问题。
www.synapsesocial.com/papers/69d8ad33d2f7327e70ae3eb5 — DOI: https://doi.org/10.1177/019262338601400108
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