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柠檬酸盐是细胞能量代谢中的重要底物。它在线粒体中生成,并在线粒体内通过特定的线粒体载体CIC释放到细胞质中,或用于柠檬酸循环。在细胞质中,柠檬酸盐及其衍生物乙酰辅酶A和草酰乙酸参与正常及病理过程。除了作为经典的代谢调节剂,近期研究强调柠檬酸盐涉及炎症、癌症、胰岛素分泌、组蛋白乙酰化、神经系统疾病及非酒精性脂肪肝病。因而监测柠檬酸盐水平变化可能作为一种诊断工具。本文综述了柠檬酸盐功能的新方面。
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Vito Iacobazzi
Vittoria Infantino
Biological Chemistry
University of Bari Aldo Moro
University of Basilicata
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies
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Iacobazzi等(Fri,)研究了这一问题。
www.synapsesocial.com/papers/6a03b0ba2a28ec6b2ef019ae — DOI: https://doi.org/10.1515/hsz-2013-0271
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