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哺乳动物的毛囊在胚胎发育期间由表皮和真皮之间的协调相互作用产生。目前尚不清楚如何在多能干细胞培养中重现毛囊诱导,以用于基础研究或体外药物测试。迄今为止,体外生成毛囊只能通过分离自胚胎皮肤的原代细胞单独培养或与干细胞衍生细胞共培养,并结合体内移植实现。本文描述了在三维培养中,由均一的小鼠多能干细胞群体衍生出的包括表皮层和真皮层的皮肤类器官。我们展示了皮肤类器官能够自发产生新生毛囊,其过程模拟正常胚胎毛囊发生。这种体外皮肤发育模型将有助于研究毛囊诱导机制、评估促进或抑制毛发生长的药物以及模拟皮肤疾病。
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Jiyoon Lee
Robert Böscke
Pei-Ciao Tang
Cell Reports
Stanford University
Indiana University – Purdue University Indianapolis
Indiana University School of Medicine
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Lee等人(Mon,)研究了这个问题。
www.synapsesocial.com/papers/6a04c46a8d238486f0ad3c2e — DOI: https://doi.org/10.1016/j.celrep.2017.12.007
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