September 28, 2025Thorax

Proteomics-based risk prediction and drug targets identification for chronic obstructive pulmonary disease

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Comparative analysis reveals protein biomarkers outperform genetic risk scores for COPD prediction, highlighting new therapeutic targets.

A developed 32-protein risk score strongly predicted incident COPD with a C-index of 0.826, indicating high accuracy.
Additional clinical factors further improved the risk prediction, showing a Net Reclassification Improvement between 0.251 and 0.318.
Mendelian randomisation analysis revealed key proteins like ADM and SCGB1A1 as protective factors against COPD risk.
Pathway analysis highlighted inflammatory mechanisms and the role of matrix metalloproteinase-9 in COPD progression.

Zhang et al. (2025) studied this question.

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September 28, 2025Thorax

View Full Paper

Ask AI

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Authors

Comparative analysis reveals protein biomarkers outperform genetic risk scores for COPD prediction, highlighting new therapeutic targets.

A developed 32-protein risk score strongly predicted incident COPD with a C-index of 0.826, indicating high accuracy.
Additional clinical factors further improved the risk prediction, showing a Net Reclassification Improvement between 0.251 and 0.318.
Mendelian randomisation analysis revealed key proteins like ADM and SCGB1A1 as protective factors against COPD risk.
Pathway analysis highlighted inflammatory mechanisms and the role of matrix metalloproteinase-9 in COPD progression.

Zhang et al. (2025) studied this question.

View Full Paper

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Bookmark