This research demonstrates a novel approach to halogenation of α-tertiary amines, highlighting deaminative halogenation and functional group compatibility.
Key Points
The study showcases a radical-mediated approach for halogenation, simplifying reactions at crowded tertiary centers.
Efficient halogenation, including chlorination, bromination, and iodination, is achieved with diverse amine substrates.
The methodology opens pathways for late-stage molecular diversification with excellent functional group compatibility.
A broad substrate scope is combined with operational simplicity, potentially aiding drug candidate development.