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October 9, 2025Open Access

Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial

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Authors

RRRodosthenis S. RodosthenousLVLeena E. ViiriACAnne Carson

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Overview

Randomized trial assessed weight loss in adults with high versus low genetic predisposition to BMI, revealing no interaction with dietary intervention.

Key Points

  • No significant difference in weight loss was observed based on genetic predisposition to BMI.
  • At 6 months, participants with high genetic predisposition lost an average of 4.70% of their weight with dietary intervention.
  • This randomized controlled trial compared weight loss between two groups over a 6-month period with controlled dietary intake.
  • These findings suggest that genetic predisposition may not enhance personalized dietary weight loss strategies.

Cite This Study

Rodosthenous et al. (2025) studied this question.

synapsesocial.com/papers/68e70db790569dd607ee674ehttps://doi.org/10.1101/2025.10.06.25337395
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dietary intervention and BMI reduction in individuals at the extremes of genetic predisposition to higher BMI: a randomized controlled trial2026
  2. 2Abstract P492: Polygenic Risk for Obesity and Race Modify the Effect of a Low Fat Dietary Clinical Trial on Weight Loss2024
  3. 3Effects of Personalized Nutrition Education Tailored to Individual Genetic Risk Profiles on Weight Loss in Adults with Obesity: A Randomized Controlled Trial2026
  4. 4Effect of Knowledge of Personal Metabolic-Trait SNP Genotypes with Tailored Lifestyle Recommendations on Body Weight and Body Composition: A Randomized Controlled Trial2026
  5. 5Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention2022 · 11 citations