Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 11, 2025The American Journal of Surgical Pathology

Patterns of Gastrointestinal Injury Associated With CAR-T Therapy for Patients With Multiple Myeloma

View Full Paper
Ask AI
Bookmark
Share

Authors

LOLeah OsnisJHJohn HartAOAndrea D. Olivas

Discussion

Loading...

Member takes

Overview

Retrospective study shows unique intestinal injury patterns in multiple myeloma with CAR-T therapy, indicating the need for careful evaluation.

Key Points

  • This research investigates gastrointestinal changes related to CAR-T therapy in multiple myeloma patients.
  • Conducted a retrospective study of 10 patients receiving CAR-T therapy for multiple myeloma.
  • Collected and analyzed 26 gastrointestinal biopsy specimens.
  • Assessed biopsy findings across different gastrointestinal regions.
  • Specimens showed reduced or absent plasma cells, especially in the small intestine.
  • Notable findings included lymphocytic infiltration, villous atrophy, and increased apoptotic bodies.
  • The duodenum showed more severe injury compared to the colon, highlighting evaluation needs.

Cite This Study

Osnis et al. (2025) studied this question.

synapsesocial.com/papers/69401b262d562116f28f7803https://doi.org/10.1097/pas.0000000000002499
View Full Paper
Ask AI
Bookmark
Share