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January 23, 2026Journal of Crohn s and Colitis

P0663Comparative Effectiveness of Advanced Therapies between Ulcerative Proctitis and More Extensive Forms of Ulcerative Colitis: Results from a Multicenter Real-World Study

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Authors

MHM HupéMUM UzzanRAR. Altwegg

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Overview

Multicenter analysis compares treatment effectiveness for ulcerative proctitis and extensive colitis, indicating similar outcomes.

Key Points

  • This study aims to compare the effectiveness of advanced therapies in patients with ulcerative proctitis versus those with extensive ulcerative colitis.
  • Pooled individual-level data from multicenter, retrospective studies.
  • Included patients with active ulcerative colitis who initiated advanced therapy after prior biologic failure.
  • Primary outcome was steroid-free symptomatic remission at week 14, adjusted for confounders.
  • Secondary outcome evaluated discontinuation-free survival.
  • Subgroup analyses by therapeutic class were conducted.
  • A total of 608 patients included, with 73 having ulcerative proctitis and 535 having extensive disease.
  • No significant differences in remission rates between ulcerative proctitis and extensive forms (OR = 1.75, p = 0.13).
  • Elevated partial mayo score was associated with lower remission rates (OR = 0.84, p = 0.004).
  • No differences in treatment discontinuation time between groups (HR = 0.78, p = 0.20).
  • Subgroup analyses showed no significant differences in efficacy among therapeutic classes based on disease extent.

Cite This Study

Hupé et al. (2026) studied this question.

synapsesocial.com/papers/69730fc4c8125b09b0d1f8d3https://doi.org/10.1093/ecco-jcc/jjaf231.844
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