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July 12, 2017Science Translational Medicine1,088 citations

Detecting human coronary inflammation by imaging perivascular fat

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AAAlexios S. AntonopoulosCardiac ImagingFSFabio SannaUniversity of SassariNSNikant SabharwalCardiac Imaging

Key Result

Larger adipocyte size and increased lipid content in perivascular adipose tissue are linked to lower levels of coronary inflammation and atherosclerotic plaque burden.

Key Points

  • The aim is to investigate how adipocyte size and lipid content in perivascular adipose tissue relate to coronary inflammation.
  • Analyzed adipocyte size and lipid content in perivascular adipose tissue.
  • Assessed their association with coronary inflammation and atherosclerotic plaque burden.
  • Smaller adipocyte size and lower lipid content are associated with reduced coronary inflammation.
  • A significant inverse relationship exists between perivascular fat characteristics and plaque burden.

Structured PICO

Is perivascular adipose tissue adipocyte size and lipid content associated with coronary inflammation and atherosclerotic plaque burden in human patients?

P
Population
human patients
I
Intervention
imaging perivascular fat to assess adipocyte size and lipid content
O
Outcome
coronary inflammation and atherosclerotic plaque burdensurrogate

Imaging perivascular fat to assess adipocyte size and lipid content may serve as a non-invasive marker for coronary inflammation and atherosclerotic plaque burden.

Abstract

Adipocyte size and lipid content in perivascular adipose tissue are inversely associated with coronary inflammation and atherosclerotic plaque burden in human patients.

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Cite This Study

Antonopoulos et al. (2017) studied this question. Larger adipocyte size and increased lipid content in perivascular adipose tissue are linked to lower levels of coronary inflammation and atherosclerotic plaque burden.

synapsesocial.com/papers/698cd14d8e28ec31f6cfba00https://doi.org/10.1126/scitranslmed.aal2658
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