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February 14, 20260 citationsOpen Access

First-Classness yields a unique 64 → 20 genetic code: Supplementary Documentation Package

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DMDouglas Joseph Huntington Moore

Key Points

  • This research aims to derive the genetic code's degeneracy spectrum from the concept of First-Classness, ensuring no privilege in entities or relations.
  • Derivation of genetic code's degeneracy from symmetry constraints using group theory.
  • Analysis of codon-usage data spanning approximately 1.4 million coding sequences from 70,950 genomes.
  • Cross-validation against alternative databases and variant code scenarios.
  • Identified a unique partition of 64 triplets into orbits of sizes 1, 2, 3, 4, and 6.
  • Reproduced the universal code's synonymous-family sizes through the orbit structure.
  • Highlighted special roles for codons AUG and UGG within the derived structure.

Abstract

This record deposits the manuscript “First-Classness yields a unique 64→20 genetic code: a group-theoretic derivation” (Douglas J. Huntington Moore), together with the accompanying analysis materials used to generate the reported figures and statistics. The paper derives the genetic code’s degeneracy spectrum from a symmetry constraint termed First-Classness (FC): no entity, position, or relation may be intrinsically privileged. Imposing FC on the four dispositional generators ε, η, i, j forces a unique partition of the 64 triplets into orbits of sizes 1, 2, 3, 4, and 6. Under the Rosetta mapping of these generators to the nucleotide bases A, U, G, C, this orbit structure reproduces the universal code’s synonymous-family sizes and identifies special singleton roles for AUG and UGG (with GGG as a further structural anchor within the construction). The empirical component tests FC-implied balance conditions against large-scale codon-usage data, including RefSeq-based species tables spanning 70, 950 genomes (aggregating approximately 1. 4 million coding sequences), and additional cross-checks against alternative databases and variant-code cases (notably ciliate variants). The deposited software package contains scripts for orbit enumeration, statistical analysis, and figure generation, along with the processed codon-usage tables and the corresponding outputs, enabling direct reproduction of the paper’s key plots (orbit distributions, sixfold fine-structure comparisons, and variant-code validation). If you are packaging only the manuscript (without the software/data), delete the second and third paragraphs and retain only the first paragraph plus a single sentence stating: “This record contains the manuscript only. ”

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Cite This Study

Douglas Joseph Huntington Moore (2026) studied this question.

synapsesocial.com/papers/699010ce2ccff479cfe570c9https://doi.org/10.5281/zenodo.18605482
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