Dual antiplatelet therapy pretreatment in patients undergoing intravenous thrombolysis for acute ischemic stroke: a systematic review and meta-analysis of 296,854 patients

Key Points

• Evaluate the effect of dual antiplatelet therapy pretreatment on outcomes after intravenous thrombolysis for acute ischemic stroke.
• Systematic review of studies including 296,854 patients
• Assessment of functional outcomes and mortality
• Analysis of risks associated with sICH defined by NINDS criteria
• Prestroke DAPT was not linked to favorable functional outcomes
• No reduction in mortality observed
• Associated with a 1% absolute risk increase in sICH

Abstract